Healthy volunteer, bipolar disorder.
Conditions
Sponsors
National Institute of Radiological Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: I. Patients 20 y.o.<=Age patients with bipolar disorder or shizoaffective disorder II. Healthy volunteers 20 y.o.<=Age normal subjects
Exclusion criteria
Exclusion criteria: I. Patients 1. Subjects with other psychiatric diseases 2. Subjects with any organic brain disorder 3. Subjects with a severe physical complication 4. Subjects who has been taking papaverine or xanthine 5. Subjects with metallic medical device in the body 6. Subjects with tattoo 7. Subjects with severe claustrophobia 8. Subjects who tends to suicide 9. Pregnant women 10. Subjects who is considered to be inappropriate to participate in the study II. Healthy volunteers 1. Subjects with any psychiatric disorder 2. Subjects with any organic brain disorder 3. Subjects with severe physical complication 4. Subjects who has been taking papaverine or xanthine 5. Subjects who has been taking any dopamine blocker 6. Subjects who currently smokes 7. Subjects with metallic medical device in the body 8. Subjects with tattoo 9. Subjects with severe claustrophobia 10. Pregnant women 11. Subjects who has participated in other study in recent 6 months. 12. Subjects who is considered to be inappropriate to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Binding potential measured by positron emission tomography with [18F]MNI659 and [18F]PM-PBB3 | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlations between central PDE10A and tau deposition and various clinical scales Difference of binding potential of [18F]MNI659 between manic state and depressive state. | — |
Countries
Japan
Contacts
Public ContactKeisuke Takahata
National Institute of Radiological Sciences Department of Functional Brain Imaging Research
Outcome results
None listed