Healthy people
Conditions
Interventions
Conduct evaluation 1) to 3) with 2 weeks interval. 1)Wash forearm ->
3 hours application of 3 different concentration of "
composition A"
and "
placebo"
->
evaluation of skin redness induced by ammonia aqueous solution. 2)Wash forearm ->
3 hours,3 times,3 days application of 4 different concentration of "
. ->
evaluation of skin redness induced by ammonia aqueous solution and tape-stripping of stratum corneum. 3)Wash forearm ->
3 hours application of 4 different concentration of "
tape-stripping of stratum corneum.
Sponsors
Kao Corporation
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1) 20-49 years old healthy man 2) Men who have healthy and non-troubled skin on their forearm
Exclusion criteria
Exclusion criteria: -Man who have dermatitis (atopic dermatitis etc.). -Man under-medication. -Man who have experience of skin troubled with products containing ammonium aqueous solution. -Man who is judged as "not eligible" by investigator. For example, man who have sunburned skin, man who have pigmentation, man who have hairy skin, man who have significant skin contour by his mascule and blood vessel.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Skin redness induced by ammonia aqueous solution after 3 days third times consecutive 3 hours application (total 9 hours application in a day) of "composition A" and "placebo" | — |
Secondary
| Measure | Time frame |
|---|---|
| Stratum corneum components related with skin redness induced by ammonia aqueous solution after 3 days application (third times consecutive 3 hours application, total 9 hours application in a day) of "composition A" and "placebo" Skin redness induced by ammonia aqueous solution after 3 hours application of "composition A", "placebo" and "composition B". Amount of "composition A" and "composition B" transferred to skin after 3 hours application of "composition A", "placebo" and "composition B". | — |
Countries
Japan
Contacts
Public ContactMaeko Iwamura
Kao Corporation Biological Science Research
Outcome results
None listed