Study on Clinical Effects of Toothpaste Containing Propolis in Periodontitis Patients

Study on Clinical Effects of Toothpaste Containing Propolis in Periodontitis Patients - Effects of Toothpaste Containing Propolis in Periodontitis Patients

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000029554

Enrollment

Registered

2017-10-14

Start date

2017-02-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontitis

Interventions

Tooth brushing with given toothbrush and toothpaste containing 5 mg/g propolis twice a day for 4 weeks Tooth brushing with given toothbrush and toothpaste not containing propolis twice a day for 4 wee

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Periodontitis patients in supportive periodontal therapy (SPT) phase (consulting period: more than 2 months interval) at Department of Periodontics and Endodontics of Okayama University Hospital 2) Good oral hygiene; good compliance during study period, judged by research dentist 3) Age is not less than 20 years old when obtaining informed consent. 4) Current number of teeth is not less than 20. 5) Patients with 3 or more teeth with 4- to 6-mm periodontal pocket 6) Patients with informed consent by document agree

Exclusion criteria

Exclusion criteria: 1) Allergic for this toothpaste 2) Pregnancy or lactating period women 3) Unstable physical condition 4) Use of antibiotics / anti-inflammatory agents within 3 months 5) Acute symptom of periodontitis within 3 months 6) Smoker 7) Unifit patients judged by research dentists for compliance

Design outcomes

Primary

Measure	Time frame
Amounts of bacteria in sub-gingival dental plaque after 4 weeks (Total bacteria and Porphyromonas gingivivalis)	—

Secondary

Measure	Time frame
Nine points after 4 weeks 1) Probing pocket depth 2) Bleeding on probing 3) Activity of neutrophil elastase and total protein amounts in saliva 4) Ammonia in saliva 5) Cariogenic activity of saliva: amounts of cariogenic bacteria, acidity, buffer capacity 6) Microflora of sub-gingival dental plaque analyzed by next generation sequencer (2 subjects/group) 7) Questionnaire for impression of use of this toothpaste and its effective 8) Record of implementation 9) Questionnaire for the condition of pre-existing disease	—

Measure

Time frame

Nine points after 4 weeks 1) Probing pocket depth 2) Bleeding on probing 3) Activity of neutrophil elastase and total protein amounts in saliva 4) Ammonia in saliva 5) Cariogenic activity of saliva: amounts of cariogenic bacteria, acidity, buffer capacity 6) Microflora of sub-gingival dental plaque analyzed by next generation sequencer (2 subjects/group) 7) Questionnaire for impression of use of this toothpaste and its effective 8) Record of implementation 9) Questionnaire for the condition of pre-existing disease

—

Countries

Japan

Contacts

Public ContactShogo Takashiba

Okayama University Department of Pathophysiology - Periodontal Science, Okayama University Graduate School of Medicine,

stakashi@okayama-u.ac.jp086-235-6675

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026