Lung-protective properties of expiratory flow-initiated pressure-controlled inverse ratio ventilation: A randomised controlled trial

Lung-protective properties of expiratory flow-initiated pressure-controlled inverse ratio ventilation: A randomised controlled trial - Lung-protective properties of expiratory flow-initiated pressure-controlled inverse ratio ventilation: A randomised controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000029552

Enrollment

Registered

2017-11-01

Start date

2017-11-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Consecutive subjects undergoing robot-assisted laparoscopic radical prostatectomy

Interventions

Volume control ventilation group Targer PaO2&gt

100 mmHg and PaCO2&lt

50 mmHg. Volume control ventilation mode. I:E ratio of 1:2. PEEP of 5 cmH2O. Tidal volume of 6~8 ml/kg body weight. Airway pressure &lt

30 cmH2O. Initial respiratory rate of 12 bpm up to 18 bpm. Expiratory flow initiated pressure control inverse ratio ventilation group Targer PaO2&gt

50 mmHg. PCV volume guarantee mode. PEEP off. Tidal volume of 6~10 ml/kg body weight. Airway pressure &lt

25 cmH2O. Inverse I/E ratio was adjusted individually by observing the expiratory flow-time wave. Initial respiratory rate of 12 bpm up to 15 bpm.

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: American Society of Anaesthesiologists (ASA)physical status I or II scheduled to undergo elective RLRP.

Exclusion criteria

Exclusion criteria: History of pneumothorax, previous lung surgery, and ASA physical status III or worse

Design outcomes

Primary

Measure	Time frame
IL-6 of arterial blood sampling obtained at the start, 2 hour later and end of surgery.	—

Secondary

Measure	Time frame
IL-8, IL-1, TNF physiological dead space, airway dead space, alveolar dead space, shunt dead space, respiratory-haemodynamic parameters	—

Countries

Japan

Contacts

Public ContactGo Hirabayashi

Mizonokuchi Hospital, Teikyo University School of Medicine Anesthesiology

flatwood@aa.cyberhome.ne.jp044-844-3333

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026