Comparison of the effect on the postoperative pain between intravenous acetaminophen and flurbiprofen after total knee arthroplasty: a randomized controlled trial

Comparison of the effect on the postoperative pain between intravenous acetaminophen and flurbiprofen after total knee arthroplasty: a randomized controlled trial - Comparison of the effect on the postoperative pain between intravenous acetaminophen and flurbiprofen after total knee arthroplasty: a randomized controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000029487

Enrollment

Registered

2017-10-10

Start date

2017-10-11

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis of the knee

Interventions

Intravenous acetaminophen (1000mg) administration 15 minutes before the end of operation, and 6, 12, 18, and 24 hours after the operation. Flurbiprofen (50mg) administration 15 minutes before the end

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The patients weighing 50-70 kg and undergoing elective total knee arthroplasty.

Exclusion criteria

Exclusion criteria: 1. ASA physical status 3-6 2. Liver or renal dysfunction 3. Past history of peptic ulcer or asthma 4. Allergy to acetaminophen or NSAIDs or local anesthetics

Design outcomes

Primary

Measure	Time frame
Postoperative pain evaluated by Numerical Rating Scale (NRS) during first 24 h after total knee arthroplasty.	—

Countries

Japan

Contacts

Public ContactYusuke Kasai

Nagasaki Rosai Hospital Department of anesthesia

gokiten@yahoo.co.jp0956-49-2191

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026