Efficacy and safety of cold snare polypectomy with submucosal injection for small colorectal polyps. A randomized controlled study.

Efficacy and safety of cold snare polypectomy with submucosal injection for small colorectal polyps. A randomized controlled study. - CSP-SI trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000029441

Enrollment

214

Registered

2017-10-27

Start date

2017-10-26

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

colorectal neoplastic polyp

Interventions

Cold snare polypectomy with submucosal injection Conventional cold snare polypectomy without submucosal injection

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who has undergone colonoscopy within years and has one colorectal polyp endoscopically diagnosed as colorectal adenoma or sessile serrated adenoma/polyp (3mm-10mm)

Exclusion criteria

Exclusion criteria: 1. Pregnancy 2. Inflammatory bowel disease, Familial polyposis 3. Bleeding tendency (Platelet count <80000/ul or prothrombin percentage activity <40%, PT-INR>3.0 among the patients with warfarin) 4. Multiple antithrombotic therapy 5. Poor bowel preparation 6. Invasive cancer 7. History of participant in this study

Design outcomes

Primary

Measure	Time frame
Complete muscularis mucosa resection rate	—

Secondary

Measure	Time frame
The rate of lateral and vertical margin, intraprocedual bleeding major/minor delayed bleeding, perforation and fragmentation of resected specimens. Success rate of the allocated procedure.	—

Countries

Japan

Contacts

Public ContactYuichi Shimodate

Kurashiki Central Hospital Gastroenterology and Hepatology

ys13544@kchnet.or.jp086-422-0210

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026