Major Depression
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1) Having a diagnosed of DSM-IV Major Depressive Disorder confirmed with the SCID 2) GRID-HAMD-17>=14 3) can attend session more than 8 4) 20 yo <= age <70 yo 5) can obtain written consent
Exclusion criteria
Exclusion criteria: 1)No alcohol or substance use disorder in 12 months prior to the screening. 2)No history or concurrent manic or psychotic episode. 3)No other primary DSM-IV Axis I Disorders at screening. 4)No comorbid of antisocial personality disorder. 5)No serious suicidal ideation at screening 6) No organic brain lesions or major cognitive deficits in a year prior to the screening. 7)No severe or unstable medical co-morbidities at screening. 8)No past treatment of individual CBT. 9)No structured psychotherapy during the intervention. 10)Other relevant reason decided by the i-CBT principal investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Baseline reduction score of GRID-Hamilton Depression Rating Scale (GRID-HAMD) at 16wk 2. Drop-out rate | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Baseline reduction score of GRID-Hamilton Depression Rating Scale (GRID-HAMD) at 28 and40wk 2. Beck Depression Inventory (BDI-II), Ruminative Responses Scale (RRS), Sheehan Disability Scale (SDISS):0,8,16,28,40 wks 3. Quick Inventory of Depressive Symptomatology (QIDS), Euro-Qol(EQ-5D), Session Rating Scale (SRS) at each session 4.Short Working Alliance Inventory (WAI-S):1,8,16 wks 5.Client satisfaction questionnaire (CSQ-8j):8,16,28,40 wks | — |
Countries
Japan
Contacts
Keio University School of Medicine Department of Neuropsychiatry