Hypertension
Conditions
Interventions
Four capsules containing Umezu polyphenols (200 mg per capsule) daily for 12 weeks, followed by 2 weeks of wash-out period and 12 months of follow-up period with mail surveys every 3 months.
Four plac
Sponsors
Wakayama Medical University
Kindai University Wakayama Industry Promotion Foundation
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: People with high-normal blood pressure (systolic blood pressure (SBP), 130-139 mmHg; or diastolic blood pressure (DBP), 85-89 mmHg) or low- and moderate-risk grade I hypertension (SBP, 140-159 mmHg; or DBP, 90-99 mmHg) at the clinic, taking no antihypertensive agents. (Recruited from people living in or working for a corporation in Minabe Town, Wakayama Prefecture, Japan, pursuant to Guidelines for the Management of Hypertension JSH 2009, published by the Japanese Society of Hypertension.)
Exclusion criteria
Exclusion criteria: (1) People who eat two or more Umeboshi (pickled plums) per day regularly, (2) people with ingestion difficulty, (3) people with history of serious chronic conditions including cerebrovascular disease, ischemic heart disease and cancer (malignant tumor), (4) people under medication for hypertension, (5) people who are pregnant or within 1 year after delivery, (6) people having night-shift work with night duty, (7) people who cannot participate in follow-up blood pressure measurements, and (8) people whose participation is judged to be inappropriate due to any other reason by the responsible physician.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Decrease of systolic blood pressure and diastolic blood pressure after 12 weeks of intake of Umezu polyphenols in (1) blood pressure at home, and (2) blood pressure at the examination site | — |
Secondary
| Measure | Time frame |
|---|---|
| Findings from blood tests (hematology and biochemistry) Anthropometric factors Self-perceived physical and mental health status evaluated with SF-8 Self-perceived Symptoms Changes in data of annual health checkups | — |
Countries
Japan
Contacts
Public ContactShigeki Takemura
Wakayama Medical University Department of Hygiene, School of Medicine
Outcome results
None listed