EXcreTed urinary glycans ANalysis and diagnosis of kidney disease without renal Tissue specimens(Extant)Study

EXcreTed urinary glycans ANalysis and diagnosis of kidney disease without renal Tissue specimens(Extant)Study - Extant Retrospective Study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000029336

Enrollment

460

Registered

2017-10-01

Start date

2017-10-26

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Kidney disease

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with renal biopsy 1. Patients who underwent renal biopsy from December 1, 2000 to September 30, 2017 and were diagnosed with kidney disease. 2. Patients who were enrolled into previous clinical studies of our department(No: 1009 and No: 1509-005[2063]). Healthy volunteers 1 1. Donors of kidney transplantation in our hospital since July 1, 2017 2. Donors without urine abnormalities such as hematuria and proteinuria. 3. Donors who are not diagnosed with any kidney disease in the results of 0 hour-renal biopsy. 4. Donors who agree to keep their blood and urine sample in OKADAI BIOBANK (Biobank of Okayama university hospital). Healthy volunteers 2 1. People who were registered as healthy volunteers in a clinical study (No: 1702-026, Okayama university hospital) 2. People without urine abnormalities (hematuria and proteinuria) 3. People without metabolic syndrome

Exclusion criteria

Exclusion criteria: Patients with renal biopsy Patients who withdraw the agreement of previous clinical studies of our department (No: 1009 and No: 1509-005[2063]). Healthy volunteers 1 and 2 People who decline the entry of this study.

Design outcomes

Primary

Measure	Time frame
Differenciating IgA nephropathy from other kideny disease and/or non-kidney disease	—

Secondary

Measure	Time frame
I Urinary glycan biomarker for investigatiing differencial diagnosis 1. To differenciate IgA nephropathy from other kideny disease 2. To differenciate diabetic nephropathy from other kideny disease 3. To differenciate nephrosclerosis from other kideny disease 4. To differenciate obesity-related glomerulopathy from other kideny disease 5. To differenciate membranous nephropathy from other kideny disease 6. To differenciate minimal change disease from other kideny disease 7. To differenciate Lupus nephropathy from other kideny disease 8. To differenciate ANCA-associated vasculitis from other kideny disease II Investigation of the relationship of urinary glycan profile with renal outcome, cardiovascular event, and mortality. 1. eGFR 30-40% decline from baseline 2. eGFR decline > 3-5 ml/min/1.73m2/year 3. Commencement of dialysis or renal transplantation because of end stage renal disease 4. Development of albuminuric stage 5. Mortality 6. Cardiovascular event for admission III. Examination of the association between histopathologic parameters and urinary glycan excretion	—

Measure

Time frame

I Urinary glycan biomarker for investigatiing differencial diagnosis 1. To differenciate IgA nephropathy from other kideny disease 2. To differenciate diabetic nephropathy from other kideny disease 3. To differenciate nephrosclerosis from other kideny disease 4. To differenciate obesity-related glomerulopathy from other kideny disease 5. To differenciate membranous nephropathy from other kideny disease 6. To differenciate minimal change disease from other kideny disease 7. To differenciate Lupus nephropathy from other kideny disease 8. To differenciate ANCA-associated vasculitis from other kideny disease II Investigation of the relationship of urinary glycan profile with renal outcome, cardiovascular event, and mortality. 1. eGFR 30-40% decline from baseline 2. eGFR decline > 3-5 ml/min/1.73m2/year 3. Commencement of dialysis or renal transplantation because of end stage renal disease 4. Development of albuminuric stage 5. Mortality 6. Cardiovascular event for admission III. Examination of the association between histopathologic parameters and urinary glycan excretion

—

Countries

Japan

Contacts

Public ContactKoki Mise

Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Department of Nephrology, Rheumatology, Endocrinology and Metabolism

kokims-frz@okayama-u.ac.jp086-235-7235

Outcome results