Potential roles of neurotransmitter receptors and mitochondria in the pathophysiology of autism spectrum disorder: A PET study

Potential roles of neurotransmitter receptors and mitochondria in the pathophysiology of autism spectrum disorder: A PET study - Neurotransmitter receptors and mitochondria in autism spectrum disorder

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000029183

Enrollment

Registered

2017-11-15

Start date

2017-10-31

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Autism spectrum disorder

Interventions

We use[11C]-FLB457 and [18F]BCPP-EF as radiotracer by administration intravenously

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: Health control -Without past or current history psychiatric illness Illnesses groups -Diagnosed as autism spectrum disorder on DSM-5 -Full IQ above 70 -Without nervous disease

Exclusion criteria

Exclusion criteria: -With current history of brain organic diseases

Design outcomes

Primary

Measure	Time frame
The binding potentials of [11C] FLB and standard uptake value ratio of [18F] BCPP-EF	—

Secondary

Measure	Time frame
Indices assessed with MRI Psychological tests : ADOS-2(Autism Diagnostic Observation Schedule Second Edition),ADI-R(Autism Diagnostic Interview-Revised),AQ(Autism-Spectrum Quotient),STAI(State-Trait Anxiety Inventory),SASS( Social Adaptation Self-evaluation Scale),CES-D(The Center for Epidemiologic Studies Depression Scale),CGI-S( Clinical Global Impressions-Severity of Illness scale),WAIS-3(Wechsler Adult Intelligence Scale third edition) Labo date:lactate,pyruvate,ammoniaasparate aminotransferase,alanine aminotransferase,creatine kinase, creatinine	—

Measure

Time frame

Indices assessed with MRI Psychological tests : ADOS-2(Autism Diagnostic Observation Schedule Second Edition),ADI-R(Autism Diagnostic Interview-Revised),AQ(Autism-Spectrum Quotient),STAI(State-Trait Anxiety Inventory),SASS( Social Adaptation Self-evaluation Scale),CES-D(The Center for Epidemiologic Studies Depression Scale),CGI-S( Clinical Global Impressions-Severity of Illness scale),WAIS-3(Wechsler Adult Intelligence Scale third edition) Labo date:lactate,pyruvate,ammoniaasparate aminotransferase,alanine aminotransferase,creatine kinase, creatinine

—

Countries

Japan

Contacts

Public ContactKato Yasuhiko

Hamamatsu University school of medicine psychiatry

katounagi.y@gmail.com09061277594

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026