The study of biomarkers for intractable vascular anomalies and associated with pharmacological action of sirolimus

The study of biomarkers for intractable vascular anomalies and associated with pharmacological action of sirolimus - The study of biomarkers for intractable vascular anomalies

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000029173

Enrollment

Registered

2017-09-17

Start date

2017-12-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vascular anomalies

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Intractable vascular anomalies

Exclusion criteria

Exclusion criteria: 1. Patients with a history of hypersensitivity to ingredients of this drug 2. Patients with serious liver and renal disorders 3. Patients with symptoms that affect cytokine value of such obvious infection at the time of specimen collection 4. Patients must also avoid strong inducers of CYP3A4 5. Past usage of mTOR inhibitors or other molecular target drugs relating mTOR pathway 6. Patient who is judged inappropriate to participate in this study by the investigators

Design outcomes

Primary

Measure	Time frame
The relativity between the efficacy and safety of the sirolimus treatment and cytokine	—

Secondary

Measure	Time frame
The difference of disease-specific biomarkers for vascular anomalies. The change of cytokine after sirolimus treatment.	—

Countries

Japan

Contacts

Public ContactMichio Ozeki

Gifu University Hospital The department of Pediatrics

michioo@gifu-u.ac.jp058-230-6000

Outcome results