Healthy adult
Conditions
Interventions
Ingestion of 200 mL of vegetable juice three times a day before each meal for 8 weeks
Sponsors
The KAITEKI Institute, Inc.
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. Japanese male healthy volunteers above 50 and below 70 years of age when written informed consent is obtained. 2. Subjects whose abdominal circumference is 85 cm or more at the time of preliminary examination 3. Subjects who have a high LDL cholesterol level at preliminary inspection (As a guide, 120 mg / dL or more) 4. Subjects who have a high TG level at preliminary inspection (As a guide, 100 mg / dL or more, less than 400 mg / dL) 5. Subjects who can visit medical institution on scheduled visit date 6. Subjects who realize the object and contents of the study and submit the written informed consent
Exclusion criteria
Exclusion criteria: 1. Subjects who develop diabetes Fasting blood glucose: 126 mg / dL or more or HbA 1 c: 6.5% or more 2. Subjects who have systolic blood pressure of 180 mmHg or more or diastolic blood pressure of 110 mmHg or more 3. Subjects who have current medical history of serious heart disease (heart failure, myocardial infarction, myocarditis, etc.), liver function disorder or renal disorder injury 4. Subjects who donated 400 mL of blood within 12 weeks before starting ingestion, 200 mL of blood within 4 weeks or donor ingredient donation (plasma component donation and blood platelet component donation) within 2 weeks 5. Subjects who are participating in other examination or within 4 weeks of examination end 6. Subjects who are at risk of having allergic reactions to raw materials of test foods, or to metals 7. Subjects who have experienced a feeling defect or physical condition deterioration due to blood sampling in the past 8. Heavy drinkers(averaged 40 g equivalent amount / day or more in terms of pure alcohol amount) 9. Excessive smokers (average 21 / day or more) 10. Subjects who have constipation (as a guide, twice a week or less) or have chronic diarrhea 11. Subjects with extremely irregular eating habits (extreme food starters, shift workers, etc.) 12. Subjects who take prescribed medicine which would affect the lipid metabolism 13. Subjects who regularly take medicine, functional foods, and/or supplements which would affect the lipid metabolism, excluding those who can stop taking them after informed consent). 14. Subjects who have a history of large surgery on the gastrointestinal tract such as gastrectomy, gastrointestinal suture, intestinal resection (excluding cecal resection) 15. Subjects who are judged as ineligible to participate in the study for other reasons by the principal investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total cholesterol, LDL cholesterol, Triglyceride(TG) | — |
Countries
Japan
Contacts
Public ContactJunko Fujii
New Drug Research Center Inc. Clinical Research Development
Outcome results
None listed