Myalgic encephalomyelitis/chronic fatigue sydnrome (ME/CFS) and healthy control
Conditions
Interventions
None listed
Sponsors
Osaka City University
RIKEN, Kyushu University, Yamaguchi University, Kansai University of Welfare Sciecnes, Nakatomi Fatigue Care Clinic, MI Clinic, Mie University, Astellas
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Meet diagnosis both CDC criteria (1994) and ME/CFS (2003)
Exclusion criteria
Exclusion criteria: 1) Pregnant women, those who are likely to become pregnant, those who are breastfeeding 2) Person who has metal, pacemaker in the body by surgery etc. 3) Claudophobia 4) Persons who have a history of feeling sick during blood sampling 5) Persons who are experiencing psychiatric diseases before suffering chronic fatigue syndrome 6) Person who has fatigue performance status less than 4 7) A person who falls under the exclusionary disorder in ME/CFS clinical diagnostic criteria(2016) of the Ministry of Health, Labor and Welfare, a person who has undergone diagnosis of cerebral spinal fluid reduction 8) Until three month's earlier PET examination, persons who are unable to stop taking drug which may affect microglial activation or Chinese medicine with anti-inflammatory effects 9) Until one month prior to the implementation of PET, persons who are unable to stop medicines that may affect microglia activation or high antipyretics analgesic drugs with COX-1 selection system 10) BMI less than 15, more than 30 11) Others who judged inappropriate by the attending physician 12) For healthy subjects, those with a history of anemia, those with chronic fatigue and malaise, those with a history of surgery within six months, those with a history of psychiatric diseases, workers with working over 100 hours per month or shift worker with night shift, person with sleep disorder, person who has been reexamined by health check within 6 months, more than 2 in fatigue performance status
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The level of brain positive inflammation dected by positron emission tomography (PET), [F18]DPA-714 | — |
Secondary
| Measure | Time frame |
|---|---|
| Oxidative stress level, Anti-oxidant activity, Metabolome, Proteome, Cytokines, Extracellular vesicles, Clinical test (CRP, cholesterol, etc.), CD antibody, Autonomic nervous system, Questionnaires for fatigue, depression and various symptoms, Arithmetic task, Sleep-wake cycle, Performance status for fatigue | — |
Countries
Japan
Contacts
Public ContactHirohiko Kuratsune
Osaka City University Graduate School of Medicine
Outcome results
None listed