Prospective Intevention Study of Propylactive and Therapeutic Ethanol-Lock Therapy for the Prevention of Catneter-Related Blood Stream Infection in Pediatric Patients with Home Parenteral Nutrition due to Intestinal Failure

Prospective Intevention Study of Propylactive and Therapeutic Ethanol-Lock Therapy for the Prevention of Catneter-Related Blood Stream Infection in Pediatric Patients with Home Parenteral Nutrition due to Intestinal Failure - Ethanol-Lock Therapy(ELT) for the Prevention of Catneter-Related Blood Stream Infection(CRBSI) in Pediatric Patients with Home Parenteral Nutrition(HPN) due to Intestinal Failure

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000029072

Enrollment

Registered

2017-09-19

Start date

2017-09-11

Completion date

Unknown

Last updated

2025-07-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pediatric Patients with Home Parenteral Nutrition due to Intestinal Failure

Interventions

single arm

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria:

Exclusion criteria

Exclusion criteria: 1) Allergy or reaction to ethanol 2) Active infection of catheter inserting portion (including subcutaneous tunnel infection) 3) To be impossible of blood backflow from catheter 4) Patients restricted ethanol by social,religious or cultural reasons 5) Other patients ineligible for this study by doctor's judgment

Design outcomes

Primary

Measure	Time frame
CRBSI frequency/1000 catheter days : Convert individual CRBSI times to HPN management days into 1000 HPN management days	—

Secondary

Measure	Time frame
1) Number of T-ELT failure/1000 caheter days 2) Number of catheter occlusion and breakage/1000 catheter days 3) Complications and side effects associated with ELT 4) Pathogenetic organisms and sensitivity for antibacterial agents 5) Number of catheter occulusion and breakage and its mechanical problems 6) Succeaa ratio of T-ELT: number of succeaa T-ELT/ number of T-ELT applications 7) Duration between last P-ELT and CRBSI	—

Measure

Time frame

1) Number of T-ELT failure/1000 caheter days 2) Number of catheter occlusion and breakage/1000 catheter days 3) Complications and side effects associated with ELT 4) Pathogenetic organisms and sensitivity for antibacterial agents 5) Number of catheter occulusion and breakage and its mechanical problems 6) Succeaa ratio of T-ELT: number of succeaa T-ELT/ number of T-ELT applications 7) Duration between last P-ELT and CRBSI

—

Countries

Japan

Contacts

Public ContactTakatsugu MUrakoshi Takatsugu Murakoshi

Tokyo Metropolitan Children's Medical Center Gastroenterology

takatsugu_muraoshi@tmhp.jp042-300-5111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Feb 4, 2026