A healthy adult
Conditions
Interventions
Intervention is a 1 day, about 3.5 hours during Study 1-3. <
Study 1>
A subject keeps and rinses 20ml of 5% alcohol beverage in his/her oral cavity for 30 seconds, 2, 5 and 10 minutes at intervals of 30 minutes. And then, he/she is sampled each solution. <
Study 2>
A subject is sampled his/her saliva 14 times for 20 minutes after keeping and rinsing 20ml of 5% alcohol beverage for 30 seconds in his/her oral cavity. <
Study 3>
A subject brushes his/her teeth and tongue and washes carefully his/her mouth using water after 30 minutes from Study 1. And then, he/she is again sampled his/her saliva in the same way as Study 2.
Sponsors
Yamaguchi University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: ?20<= years-old ?Male and Female ?A person who has ever drunken ?A person who is provided sufficient explanations about this study and consented to it in writing by his own free will
Exclusion criteria
Exclusion criteria: ?a person who has ever had any allergy symptoms by drinking alcohol beverage ?a person who has any airway diseases or liver diseases ?a person who is probably pregnant or is during pregnancy ?a person who is during the lactation ?an inappropriate person for this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| <Study1> change in alcohol and acetaldehyde concentrations in alcohol beverage kept in oral cavity <Study 2 and 3> change in salivary alcohol and acetaldehyde concentrations after mouth rinse using alcohol beverage | — |
Secondary
| Measure | Time frame |
|---|---|
| Alcohol sensitivity by alcohol patch test and ADH1B/ALDH2 genotype based on PCR method using oral mucosa. | — |
Countries
Japan
Contacts
Public ContactAyako Himemiya-Hakucho
Graduate School of Medicine, Yamaguchi University Department of Legal Medicine
Outcome results
None listed