Which is the most compatible combination of oral hypoglycemic agents that incretin action are considered used together with basal insulin? Comparison of Vildagliptin 100 mg +Metformin 500 mg vs. Vildagliptin 100 mg +Miglitol 150 mg vs. Metformin 500 mg+Miglitol 150 mg using FreeStyle Libre Pro: randomised triple crossover study

Which is the most compatible combination of oral hypoglycemic agents that incretin action are considered used together with basal insulin? Comparison of Vildagliptin 100 mg +Metformin 500 mg vs. Vildagliptin 100 mg +Miglitol 150 mg vs. Metformin 500 mg+Miglitol 150 mg using FreeStyle Libre Pro: randomised triple crossover study - Comparison of Vildagliptin 100 mg +Metformin 500 mg vs. Vildagliptin 100 mg +Miglitol 150 mg vs. Metformin 500 mg+Miglitol 150 mg using FreeStyle Libre Pro: randomised triple crossover study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000028988

Enrollment

Registered

2017-09-04

Start date

2017-09-04

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

type 2 diabetes

Interventions

FreeStyle Libre Pro is worn after admission. Vildagliptin 100 mg +Metformin 500 mg are evaluated on day 3 and day 4. Then, Vildagliptin 100 mg +Miglitol 150 mg are evaluated on day 8 and day 9. Then,

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: type 2 diabetic patients medicated with insulin glargine 300 U/ml for 3 month or longer

Exclusion criteria

Exclusion criteria: severe renal dysfunction (eGFR less than 45) judged to be unsuitable for participation for medical reasons

Design outcomes

Primary

Measure	Time frame
24h glycemic variability percentage (GVP)	—

Secondary

Measure	Time frame
24h percentage of time in target range (70~140 mg/dL) 24h mean absolute glucose (MAG) mean glucose level (24h, 00:00~06:00, 08:00~24:00) standard deviation (SD)(24h, 00:00~06:00, 08:00~24:00) coefficient of variation (CV)(24h, 00:00~06:00, 08:00~24:00) MAGE MODD ADRR HIgh blood glucose index (HBGI) Highest postprandial glucose level within 3 hours after each meal AOC (<70 mg/dL) for glycemic variability (24h)	—

Measure

Time frame

24h percentage of time in target range (70~140 mg/dL) 24h mean absolute glucose (MAG) mean glucose level (24h, 00:00~06:00, 08:00~24:00) standard deviation (SD)(24h, 00:00~06:00, 08:00~24:00) coefficient of variation (CV)(24h, 00:00~06:00, 08:00~24:00) MAGE MODD ADRR HIgh blood glucose index (HBGI) Highest postprandial glucose level within 3 hours after each meal AOC (<70 mg/dL) for glycemic variability (24h)

—

Countries

Japan

Contacts

Public ContactSoichi Takeishi

General Inuyama Chuo Hospital Department of Diabetes

souichi19811225@yahoo.co.jp0568-62-8111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026