Diabetes Functional dyspepsia
Conditions
Interventions
Endoscopic biopsy
Sponsors
Hyogo College of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Three groups: Diabetes, Functional dyspepsia and Control. 1) Outpatients (age >= 20) 2) (I) Diabetes: fasting blood sugar >= 126 mg/dl or casual blood glucose >= 200 mg/dl or HbA1c >= 6.5%. (II) Functional dyspepsia: compatible with ROME III diagnostic criteria. Requirements: [1] or [2] or both. [1] Bothersome postprandial fullness after eating a normal amount of food >= two times/week. [2] Unable to finish a normal amount of food due to early satiation >= two times/week. (III) Control: The subjects who belongs to neither (I) nor (II). 3) The patients who can understand the contents of this study and give their entry agreement to this study by documents.
Exclusion criteria
Exclusion criteria: 1) Patients with malignant diseases, gastrointestinal-organic diseases (malignancies, peptic ulcers, esophagitis, etc.) or systemic diseases (neurological disease such as Parkinson disease or metabolic diseases except for diabetes). 2) Patients with a history of surgery of the upper gastrointestinal tract (stomach and esophagus). 3) Patients with severe liver dysfunction and renal dysfunction. 4) Patients with mental disorder. 5) A pregnant woman, nursing mother or the subjects who hope pregnancy during this study term. 6) Patients whom doctors judged unsuitable as objects for this study. 7) Patients with H. pylori eradication within 6 months. 8) Patients having the following medicines: prokinetic drugs, H2 blocker, proton pump inhibitor, gastric-mucosal protectant, prostaglandin, NSAIDs, anti-depressants, anti-anxiety agents, sleep inducer, anti-psychotics drugs. However, the patients, who can discontinue those medicines for two or more weeks before study start, can participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the expression of inflammatory markers and G protein-coupled receptors among diabetes, functional dyspepsia and control subjects | — |
Countries
Japan
Contacts
Public ContactHirokazu Fukui
Hyogo College of Medicine Division of Gastroenterology, Department of Internal Medicine
Outcome results
None listed