Chronic constipation diadnosed by Rome IV criteria
Conditions
Interventions
magnesium oxide
placebo
Sponsors
Hyogo College of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Chronic constipation patient aged 20-74 years and diagnosed according to the RomeIV criteria
Exclusion criteria
Exclusion criteria: Candidates are excluded if they prescribe drug for constipation in hospital or use the over the counter medicines for constipation Everyday Candidates are excluded if they cannot use the over the counter medicines for constipation until fourteen days from consent of this study Candidates are excluded if any of the following are evident: current evidence of renal dysfuncti or cardiac disturbance or hypermagnesemia Secondary constipation candidates are excluded Candidates are excluded if take a madecine of the proton pump inhibitor or the potassium-competitive acid blocher Female patient could not be pregnant,as confirmed by a negative serum pregnancy test at the baseline visit
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| overall treatment efficacy | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Monthly responder rates and weekly change from baseline in complete spontaneous bowel movement 2.Monthly responder rates and weekly change from baseline in spontaneous bowel movement 3.colon transit time 4.Bristol stool form 5.The patient assessment of constipation quality of life (JPAC-QOL) and SF-8 6.Weekly change from baselaine in symptom score of bloating 7.Weekly change from baselaine in symptom score of abdominal discomfort 8.Weekly change from baselaine in symptom score of afeeling of remaining faces 9.Weekly change from baselaine in symptom score of severity of straining | — |
Countries
Japan
Contacts
Public ContactToshihiko Tomita
Dr. Division of Gastroenterology,Department of Internal Medicine
Outcome results
None listed