Abdominal pain or bloating after hepatectomy
Conditions
Interventions
Oral administration of Daikenchuto 5.0 g (2.5g/pack x 2 packs) per dose three times a day from postoperative day 1 to 14.
Non-treatment of daikenchuto.
Sponsors
Nagasaki University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Selection criteria at the time of obtaining informed consent 1) Patient who are scheduled to undergo hepatectomy (>= subsegmentectomy) 2) Liver Damage A 3) Age: >= 20 years 4) Patient who are orally take daikenchuto 5) Adeguate organ functions and operable patient 6) Patient who are provide written informed consent 2. Selection criteria at the time of enrollment 7) With abdominal pain or bloating on postoperative day 1 8) Patient who are enforced hepatectomy (>= subsegmentectomy)
Exclusion criteria
Exclusion criteria: 1) Emergency surgery 2) With history of hepatectomy 3) Patient who have constitutional ICG excretory defect 4) With history of gastrointestinal surgery (excluding appendectomy) 5) Patient who are scheduled to enforce a gut surgery with hepatectomy (including biliary reconstruction) 6)With inflammatory bowel disease such as ulcerative colitis or Crohn disease (including anamnestic case) 7)With history of stoma 8)Patient who are scheduled for chemotherapy, radiation therapy or radiofrequency ablation therapy within 4 weeks before enrollment, during surgery or within 14 days after surgery (during individual study period) 9) Patient who took kampo medicine or lactobacillus preparation within 4 weeks before enrollment 10) Patient who are pregnancy, possibly pregnancy, considering pregnancy or lactating 11) Patient who are determined not applicable for the study by the physician
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Patient assessment of Postoperative abdominal pain or bloating (NRS). | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Postoperative hospital stay 2. Assessment of intestinal injury and nutritional status (DAO, GLP-2, RBP, TTR, Tf, Alb) 3. Liver function (AST, ALT, Al-P,GGTP, T-Bil, PT) 4. Incidence and rate of postoperative complications (Clavien-Dindo Classification) 5. Incidence and rate of postoperative infection (wound, intraperitoneal, respiratory, urinary tract and systemic infection) | — |
Countries
Japan
Contacts
Public ContactMasaaki Hidaka
Nagasaki University Graduate School of Biomedical Sciences Department of Surgery
Outcome results
None listed