None
Conditions
Interventions
chocolate (8 weeks).
Placebo chocolate (8 weeks).
Sponsors
CROee.INC
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Subjects who competent to consent and give voluntary consent in writing with full understanding after receiving explanation of this study aim and contents. 2) Subjects who are healthy adults of both sexes above 45 years old- under 69 years old and live without receiving any care supports at the point of obtaining informed consent.
Exclusion criteria
Exclusion criteria: 1) Subjects who metallic foreign bodies 2) Subjects who have history of head surgery (including childhood) 3) Subjects who have tattoo, permanent eye shadow, permanent eyebrow, and permanent eyelash extensions 4) Subjects who have history of occupational experience such as metallic abrasive, sheet-metal processing, welding, and lathe working 5) Subjects with claustrophobia 6) Subjects with nyctophobia 7) Subjects whose MMSE score is below 25 8) Subjects who are in pregnancy, lactation, or who are willing to become pregnant during this study 9) Subjects who are under treatment for chronic disorders 10) Subjects who cannot ingest aspartame L-phenylalanine compound (Subjects with phenylketonuria) 11) Subjects who participated in other clinical trial or monitor study within 1 month prior to screening 12) Subject with allergy to cacao, milk constituent and soy 13) Subjects with lactose intolerance 14) Subjects who highly intake cacao products on a daily basis (Cacao-rich chocolate: more than 70g/ week, Milk chocolate: more than 140g/ week) 15) Subjects who highly intake coffee on a daily basis (more than 3 cup of coffee/ day) 16) Subjects who intake medical chemical, quasi-drug, supplement, health food, foods for specified health use, foods with functions claims that potentially influence the outcome of this study, or subjects who plan to intake these during this study (such as health foods or supplement related to brain functions (including ginkgo leave extract, DHA and EPA) or health food containing high polyphenol (Tea of foods for specified health use(such as Iemon-Tokucha or Healthya Green Tea)) within 3 month prior to screening 17) Smokers (including subjects whose non-smoking period is less than 1 year) 18) Subjects who perform exercise more than 3 times a week * Exercise: Training exercise 19) Subjects who is ineligible for this study due to principal investigator's judgment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MRI brain image | — |
Secondary
| Measure | Time frame |
|---|---|
| 1)Specialized blood exam 2)Neuropsychological test(Paper based cognitive )tests 3)Subjective evaluation questionnaire | — |
Countries
Japan
Contacts
Public ContactShigeru Imai
CROee.INC Evidence Division
Outcome results
None listed