The effect of ingestion of eicosapentaenoic acid-rich fish oil on oxidative stress at the menstrual phase : a randomized, double-blind, placebo-controlled, parallel-group trial.

The effect of ingestion of eicosapentaenoic acid-rich fish oil on oxidative stress at the menstrual phase : a randomized, double-blind, placebo-controlled, parallel-group trial. - The effect of eicosapentaenoic acid on oxidative stress at the menstrual phase.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000028795

Enrollment

Registered

2017-08-30

Start date

2017-08-30

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

oxidative stress

Interventions

Tested material: EPA-rich fish oil Dosage: 3.6g/day Duration: consecutive two menstrual cycles Tested material: corn oil Dosage: 3.6g/day Duration: consecutive two menstrual cycles

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Healthy women subjects with the regular menstrual cycles

Exclusion criteria

Exclusion criteria: Subjects with / gynecological diseases /the menstrual discomfort as serious as needing medication /fish such as sardine or mackerel allergies /administration of regular medication or supplements which affect this study / smoker /any reason in the opinion of the lead principal investigator not to be taken part in this study

Design outcomes

Primary

Measure	Time frame
Derivatives of reactive oxygen metabolites ( d-ROMs ) and biological antioxidant potential ( BAP ) in blood at the menstrual and follicular phase	—

Secondary

Measure	Time frame
The menstrual discomfort measured as subjective evaluation before and during the menstruation	—

Countries

Japan

Contacts

Public ContactYoshihiko Mano

Sendai University Faculty of Physical Education

ys-mano@sendai-u.ac.jp0224-55-1389

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026