Fetal growth restriction and hypertensive pregnancy disorders
Conditions
Interventions
None listed
Sponsors
Mie university hospital, Department of Obstetrics and Gynecology
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Age>=20 2. Gestational age between 20 + 0 and 33 + 6 weeks in pregnant women. 3. The expected date of confinement is determined using the criteria of the guidelines for obstetrical practice in Japan (2014) in pregnant women. 4. Singleton pregnancy. 5. Written informed consent.
Exclusion criteria
Exclusion criteria: Attending physician decides to entry inappropriate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of expression of maternal serum protein and cell-free RNA between pregnant women complicated with and without placental origin of pregnancy disorders. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Pathological findings of the placenta. 2. Expression of maternal serum protein and cell-free RNA in the maternal blood. 3. Expression of protein and gene levels in the placenta. 4. Relationship between maternal blood concentration of tadalafil and urine concentration of cGMP. 5. Concentration of tadalafil in the cord blood. 6. Concentration of cGMP in the cord blood. 7. Relationship between maternal blood concentration of tadalafil and perinatal factors. 8. Relationship between concentration of tadalafil in the cord blood and perinatal factors. | — |
Countries
Japan
Outcome results
None listed