functional dyspepsia (FD)
Conditions
Interventions
measuring duodenal barrier function in FD patients, using mini ussing chamber system, and is compared to that in healthy volunteer.
mRNA is extracted from duodenal tissue, which is used for gene expre
Sponsors
Division of Gastroenterology Tohoku University Graduate School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: FD patients 1. 30 FD patients (Male/Female=1:1) who matches Rome IV criteria. 2. Performance status (PS) 0 3. age; 20 to 85 y 4. term; from 2017.9 to 2020 12 5. Informed consent was obtained Healthy volunteer 1. no medication, no symptom 2. PS0 3. age; from 20 to 69 y 4. Informed consent was obtained
Exclusion criteria
Exclusion criteria: Only healthy volunteer 1. medication such as acid suppressive drug, Nsaids, steroids or immune suppressive drug 1 month prior to the study All participants 1. past history of or scheduled abdominal surgery 2. forbidden in endoscopic examination (e.g. coagulation disorder) 3. pregnancy 4. severe healthy status 5. psychological disorder 6. those who are judged inappropriate to entry the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of difference in duodenal barrier function between FD patients and healthy volunteer | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison of the difference in duodenal barrier function among FD with or without non erosive reflux disease (NERD) and healthy volunteer | — |
Countries
Japan
Contacts
Public ContactKiyotaka Asanuma
Tohoku University Graduate School of Medicine Division of Gastroenterology
Outcome results
None listed