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Effects of strength exercise and beta-hydroxy-beta-methylbutyrate (HMB) on muscle mass and function

Effects of strength exercise and beta-hydroxy-beta-methylbutyrate (HMB) on muscle mass and function - Effects of strength exercise and beta-hydroxy-beta-methylbutyrate (HMB) on muscle mass and function

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000028560
Enrollment
160
Registered
2017-08-07
Start date
2017-10-09
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy older adults

Interventions

Phase 1 (12 weeks): Strength exercise (2 days/week) and HMB (1200 mg/day). Washout (12 weeks). Phase 2 (12 weeks): Health education (1 day/2 week) and placebo (every day) Phase 1 (12 weeks): Stre

Sponsors

Tokyo Metropolitan Institute of Gerontology
Lead Sponsor
University of Tsukuba
Collaborator

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: Participants who 1) were older women aged 65 years and more. 2) had reduced muscle mass (SMI<5.7). 3) provided informed consent for screening.

Exclusion criteria

Exclusion criteria: Participants who 1) were restricted from exercising by a medical doctor. 2) were taking other supplements for muscle mass gain. 3) had impaired cardiac (e.g., with cardiac pacemaker implants), kidney, and liver functions. 4) were judged ineligible by a medical doctor.

Design outcomes

Primary

MeasureTime frame
Muscle mass

Secondary

MeasureTime frame
Muscle strength, muscle quality, skin quality, sarcopenia scale, blood samples, performance test, habitual physical activity, dietary intake, diary, and health-related questionnaire

Countries

Japan

Contacts

Public ContactYosuke Osuka

Tokyo Metropolitan Institute of Gerontology Research Team for Promoting Independence of the Elderly

osuka@tmig.or.jp03-3964-3241

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026