Invasive interventional study on the effectiveness of Hydroxyprogesterone caproate for pregnant women with previous spontaneous miscarriage or premature birth

Invasive interventional study on the effectiveness of Hydroxyprogesterone caproate for pregnant women with previous spontaneous miscarriage or premature birth - Invasive interventional study on the effectiveness of 17p for pregnant women with previous spontaneous miscarriage or premature birth

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000028518

Enrollment

Registered

2017-08-31

Start date

2017-09-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

threatened miscarriage threatened premature labor

Interventions

After informed consent, 17p(250mg) is administered once a week until 36 weeks gestation. Cervical cerclage is prohibited during the study period. It does not increase or decrease the dose of 17p.

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1) Pregnant women 2) Women with previous spontaneous miscarriage or premature birth 3) Inpatients and outpatients 4) Patients agreeing to this study in writing

Exclusion criteria

Exclusion criteria: 1) Women with artificial abortion or premature birth 2) Patients with bleeding tendency 3) Dialysis patients 4) Patients with severe mental illness 5) Severe diabetic patients with HbA1c(NGSP)>10% 6) Other patients who are inappropriate for the study according to the judgement of the doctor

Design outcomes

Primary

Measure	Time frame
the risk of delivery at less than 32 weeks, delivery at less than 34 weeks and delivery at less than 37 weeks.	—

Secondary

Measure	Time frame
cervical length and the risk of adverse event	—

Countries

Japan

Contacts

Public ContactDaisuke Higeta

Gunma University Hospital Obstetrics and gynecology

daisukeh@gunma-u.ac.jp027-220-8429

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026