Study of the symptom improvement effect of gastric acid secretion inhibitors for refluxe esophagitis patients -Randomized controlled comparative test of vonoprazan and esomeprazole-

Study of the symptom improvement effect of gastric acid secretion inhibitors for refluxe esophagitis patients -Randomized controlled comparative test of vonoprazan and esomeprazole- - Study of the symptom improvement effect of gastric acid secretion inhibitors for refluxe esophagitis patients

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000028502

Enrollment

Registered

2017-08-04

Start date

2017-08-04

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Reflux esophagitis patients

Interventions

Vonopurazan 20mg P.o.once daily,8weeks Esomeprazole 20mg P.o.once daily,8weeks

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.Patients who have freely provided written informed consent for the participation of this study after the oral or written sufficient explanation. 2.Patients who were confirmed reflux esophagitis with grade A-D of LA classification at the entry.

Exclusion criteria

Exclusion criteria: 1.Patients with a history of gastrointestinal resection or vagotomy. 2.Patients with confirmed or susupected malignant disease. 3.Pregnancy or lactation. 4.Past history of allergy for the drugs used in this therapy. 5.Ptients with sever liver dysfunction,sever renal dysfunction,sever hert dysfunction. 6.Ptients who are disqualifid for the study by physicians.

Design outcomes

Primary

Measure	Time frame
Consideration of the symptom improvement value using the interview sheet after4,8 week treatment and the endoscopic improvement effect of after 8 week treatment	—

Secondary

Measure	Time frame
The safety value of the treatment	—

Countries

Japan

Contacts

Public ContactSyuji Inoue/Sizuka Eguthi

National Hospital Organization National Kochi Hospital gastroenterology

inouesh@kochi2.hosp.go.jp088-844-3111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026