Severe asthma
Conditions
Interventions
bronchial thermoplasty(3 times every 3 weeks)
Sponsors
Japanese study group for bronchial thermoplasty(J-brothers)
Japanese study group for bronchial thermoplasty(J-brothers)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Uncontrolled severe asthma patients treated with high dose inhaled corticosteroid and long-acting beta2-agonists. 2. Eligible for fiberoptic bronchoscopy.
Exclusion criteria
Exclusion criteria: 1. Have a pacemaker, implantable cardioverter defibrillator, or other implantable electronic device. 2. Have a known sensitivity to medications required to perform bronchoscopy, including lidocaine, atropine, and benzodiazepines. 3. Have been previously treated with BT 4. Active respiratory infection 5. Asthma exacerbation or changing dose of systemic corticosteroids for asthma in the past 14 days 6. Known coagulopathy. As with other bronchoscopic procedures, patients should stop taking anticoagulants, antiplatelet agents, aspirin, and NSAIDS before the procedure with physician guidance
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QOL (quality of life)(at 3M,6M,and 12M) | — |
Secondary
| Measure | Time frame |
|---|---|
| Asthma exacerbation Emergency room visits Unscheduled physician office visits Hospitalization frequency Hospitalizations Days missed from work/school Physician's Global Evaluation of Treatment Effectiveness (GETE) assessment Therapeutic drug use Pulmonary function Adverse events (at 3M,6M,and 12M) | — |
Countries
Japan
Contacts
Public ContactAkihiro Takemasa
Dokkyo Medical University Hospital Department of Pulmonary Medicine and Clinical Immunology
Outcome results
None listed