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Study to establish the safety of using antipyretics with febrile seizures and assess whether acetaminophen could reduce the recurrent risk of febrile seizure in the same fever episode.

Study to establish the safety of using antipyretics with febrile seizures and assess whether acetaminophen could reduce the recurrent risk of febrile seizure in the same fever episode. - AAA study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000028272
Enrollment
500
Registered
2018-01-01
Start date
2015-03-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

febrile seizure

Interventions

rectal acetaminophen (10mg/ kg) every 6 hours until 24 hours after the onset of febrile seizure without any other antipyretic 24 hours after febrile seizure

Sponsors

Department of Pediatrics, Hirakata City Hospital 2-14-1 Kinya-honmachi, Hirakata, Osaka 573-1013, Japan Tel: +81-72-847-2821; Fax: +81-72-847-2825
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Children and infants who come to emergency room of Hirakata City Hospital with febrile seizures between May 1, 2015, and April 30, 2018, were considered for inclusion in the study.

Exclusion criteria

Exclusion criteria: 1)Patients with seizure over 15 minutes were excluded from the study as status epilepticus. 2)Patients with diarrhea were excluded because it is difficult to put suppositories and other pathologies may be involved such as convulsion with mild gastroenteritis . 3)Patients with epilepsy, chromosomal abnormality, inherited metabolic diseases, brain tumor, cerebral hemorrhage, hydrocephalus, and those with a history of intracranial surgery were excluded. 4)Patients who were used to prevent febrile seizuress with diazepam suppository were excluded. 5)Patients take antihistamine that may increase seizure susceptibility in patients with febrile seizures were also excluded.

Design outcomes

Primary

MeasureTime frame
The outcome is the recurrece of febrile seizure in the same fever episode.

Countries

Japan

Contacts

Public ContactShinya Murata

Hirakata City Hospital Department of Pediatrics

wildwind1980@live.jp+81-72-847-2821

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026