The effect of n-3 unsaturated fatty acids supplementation on quadriceps muscle weakness after total knee arthroplasty.

The effect of n-3 unsaturated fatty acids supplementation on quadriceps muscle weakness after total knee arthroplasty. - The effect of n-3 unsaturated fatty acids supplementation on quadriceps muscle weakness after total knee arthroplasty.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000028140

Enrollment

Registered

2017-07-11

Start date

2017-07-11

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis of the knee

Interventions

Intervention group take a daily supplements with n-3 unsaturated fatty acids(EPA645mg &amp

DHA215mg) from 30 days prior to surgery. none

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Japanese males and females 2. between 60 and 79 years old 3. primary knee osteoarthritis 4. radiographic severity classified using Kellgren-Lawrence System was grade 3 to grade 4

Exclusion criteria

Exclusion criteria: 1. patients with serious heart disease and diabetes 2. history of rheumatoid arthritis, neurological disease, and peripheral artery disease 3. patients who are taking Warfarin and n-3 unsaturated fatty acids supplements 4. smoker 5. patients with exercise habits

Design outcomes

Primary

Measure	Time frame
The Primary outcome is quadriceps muscle strength. All patients included in the study are assessed 2 times: tests are performed 1 month before surgery and 4 days after surgery.	—

Secondary

Measure	Time frame
The secondary outcomes are oxidative stress, polyunsaturated fatty acid in serum, knee swelling, knee pain.	—

Countries

Japan

Contacts

Public ContactYusuke Kubo

Kobori Orthopedic Clinic Department of Rehabilitation Medicine

yusuke.kubo11@gmail.com053-438-3133

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026