Clarification of pathophysiological roles of salusin-beta and salusion-beta-related peptides in lifestyle-related diseases.

Clarification of pathophysiological roles of salusin-beta and salusion-beta-related peptides in lifestyle-related diseases. - Clarification of pathophysiological roles of salusin-beta in lifestyle-related diseases.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000028120

Enrollment

500

Registered

2017-07-10

Start date

2017-07-14

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes mellitus, hypertension and dyslipidemia

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients who fulfills more than one of the diagnostic criteria of diabetes, hypertension and lipid disorder. Or healthy volunteer. 2. Subjects who has been signed the consent form after sufficiently informed and fully understood this study.

Exclusion criteria

Exclusion criteria: 1. Patient with vert infectious diseases 2. Patient with overt malignant tumor 3. Pregnancy 4. Subject whom director of this study disqualified

Design outcomes

Primary

Measure	Time frame
Plasma levels of salusin-beta and salusin-beta-related peptides.	—

Secondary

Measure	Time frame
1. Clinical characteristics: age, height, weight, lifestyle, duration of morbidity 2. Blood pressure, heart rate 3. Blood tests: plasma glucose, HbA1c, glycated albumin, 1.5-AG, total cholesterol, triglyceride, LDL-cholesterol, HDL-cholesterol, free fatty acid, the other biochemical measurements, complete blood count. 4. Urine tests: urine protein, urine sugar, urine blood, urine albumin/creatinine ratio 5. Insulin secretory capacity (diabetic subjects): immunoreactive insulin, C-peptide, urine C-peptide, glucagon 6. Glucose profiles by continuous glucose monitoring (diabetic subjects) 7. Endocrine examinations (1)Diabetic subjects: oral glucose tolerance test, meal tolerance test, glucagon tolerance test (2)Subjects with hypertension: captopril challenge test, furosemide-upright test, rapid ACTH test, over-night dexamethasone test 8. Diabetic complication and arteriosclerosis 1) Diabetic neuropathy (diabetic subjects): symptoms by diabetic neuropathy, Achilles tender reflex, limbs vibration tests 2) Diabetic nephropathy (diabetic subjects): urine albumin/creatinine ratio, urine protein, eGFR 3) Diabetic retinopathy (diabetic subjects): examination by Ophthalmologist 4) arteriosclerosis (subjects with lifestyle-related diseases) (1)Ischemic heart disease, cerebral arterial disease, peripheral arterial disease (2)Electrocardiogram, chest and abdominal X-ray, Holter ECG, cervical arterial echography, ankle-brachial pressure index, pulse wave velocity, limbs arterial echography	—

Measure

Time frame

1. Clinical characteristics: age, height, weight, lifestyle, duration of morbidity 2. Blood pressure, heart rate 3. Blood tests: plasma glucose, HbA1c, glycated albumin, 1.5-AG, total cholesterol, triglyceride, LDL-cholesterol, HDL-cholesterol, free fatty acid, the other biochemical measurements, complete blood count. 4. Urine tests: urine protein, urine sugar, urine blood, urine albumin/creatinine ratio 5. Insulin secretory capacity (diabetic subjects): immunoreactive insulin, C-peptide, urine C-peptide, glucagon 6. Glucose profiles by continuous glucose monitoring (diabetic subjects) 7. Endocrine examinations (1)Diabetic subjects: oral glucose tolerance test, meal tolerance test, glucagon tolerance test (2)Subjects with hypertension: captopril challenge test, furosemide-upright test, rapid ACTH test, over-night dexamethasone test 8. Diabetic complication and arteriosclerosis 1) Diabetic neuropathy (diabetic subjects): symptoms by diabetic neuropathy, Achilles tender reflex, limbs vibration tests 2) Diabetic nephropathy (diabetic subjects): urine albumin/creatinine ratio, urine protein, eGFR 3) Diabetic retinopathy (diabetic subjects): examination by Ophthalmologist 4) arteriosclerosis (subjects with lifestyle-related diseases) (1)Ischemic heart disease, cerebral arterial disease, peripheral arterial disease (2)Electrocardiogram, chest and abdominal X-ray, Holter ECG, cervical arterial echography, ankle-brachial pressure index, pulse wave velocity, limbs arterial echography

—

Countries

Japan

Contacts

Public ContactAkinori Hayashi

Kitasato University School of Medicine Endocrinology, Diabetes and Metabolism

ahayashi@kitasato-u.ac.jp042-778-8706

Outcome results