Examination of the durability density of mouthwash using the tricyclic antidepressant amitriptyline

Examination of the durability density of mouthwash using the tricyclic antidepressant amitriptyline - Basic research of amitriptyline oral rinse in healthy volunteers

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000028035

Enrollment

Registered

2017-07-01

Start date

2014-02-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

oral mucocitis

Interventions

Healthy volunteers were provided an amitriptyline solution (0.05%, 0.10% and 0.20%), and they gargle with these solution for 5 seconds each section. They gargle once a day every second day.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: healthy volunteer

Exclusion criteria

Exclusion criteria: People with inflammation and pain in the oral mucositis or using antidepressants or who used anesthetics or analgesics within 24 hours, and Pregnant women, lactating women or those who wish to become pregnant during this exam, and people who judged that person in charge is inappropriate for participation in this exam.

Design outcomes

Primary

Measure	Time frame
a feeling of irritation	—

Secondary

Measure	Time frame
a feeling of numbness, fatigue, sleepiness, and taste of oral rinse	—

Countries

Japan

Contacts

Public ContactHisako Sasaki

Kitasato University Hospital Pharmacy

hisasaki@kitasato-u.ac.jp042-778-8111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026