postoperative delirium
Conditions
Interventions
Yokukansan group take 2.5 g of yokukansan before every meal from the morning of the previous day until the morning of the operation day. After surgery, patients start taking yokukansan as soon as pos
Sponsors
Tottori University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients who need surgery for gastrointestinal cancerPatients who can start oral administration early after surgery
Exclusion criteria
Exclusion criteria: Patients with past history of hypersensitivity to yokukansan or anchusan Patients diagnosed with pseudoaldosteronism Patients diagnosed with heart failure Patients with a history of rhabdomyolysis Patients diagnosed with interstitial pneumonia Patients diagnosed with liver failure Patients who cannot start oral administration early after surgery, such as esophageal cancer patients Patients with mood disorder, schizophrenia, schizoaffective disorder, alcoholism, drug addiction Patients determined to be unable to join the clinical trial
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence rate of delirium diagnosed using DSM-5 by psychiatrists on postoperative day 1,2, and 3 | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity of delirium by Delirium Rating Scale R-98 Safety (adverse events, laboratory values, postoperative complications, postoperative mortality) | — |
Countries
Japan
Contacts
Public ContactAkimitsu Tanio
Tottori University Hospital Gastrointestinal surgery
Outcome results
None listed