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The effect of exercise preconditioning with blood flow restriction on ischemia reperfusion injury and postoperative course after total knee arthroplasty.

The effect of exercise preconditioning with blood flow restriction on ischemia reperfusion injury and postoperative course after total knee arthroplasty. - The effect of exercise preconditioning with blood flow restriction on ischemia reperfusion injury and postoperative course after total knee arthroplasty.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000027929
Enrollment
30
Registered
2017-06-26
Start date
2017-06-26
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis of the knee

Interventions

The exercise contents of the intervention group are a squat, a forward lunge, bilateral leg extension with blood flow restriction and cycle ergometer training. These exercises are performed once a wee

Sponsors

Kobori Orthopedic Clinic
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Japanese males and females 2. between 60 and 79 years old 3. primary knee osteoarthritis 4. radiographic severity classified using Kellgren-Lawrence System was grade 3 to grade 4

Exclusion criteria

Exclusion criteria: 1. patients with serious heart disease and diabetes 2. history of rheumatoid arthritis, neurological disease, and peripheral artery disease 3. patients with abnormalities of blood coagulation and fibrinolysis 4. smoker 5. patients who cannot exercise due to knee pain

Design outcomes

Primary

MeasureTime frame
The Primary outcome is quadriceps muscle strength. All patients included in the study are assessed 5 times: tests are performed 3 months and 1 week before surgery, 4 days, 1 month and 3 months after surgery.

Secondary

MeasureTime frame
The secondary outcomes are knee swelling, knee range of motion, performance test, knee injury and osteoarthritis outocome score, and Japanese knee osteoarthritis measure.

Countries

Japan

Contacts

Public ContactYusuke Kubo

Kobori Orthopedic Clinic Department of Rehabilitation Medicine

yusuke.kubo11@gmail.com053-438-3133

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026