Measurement of the penetration effect of S-flurbiprofen into the knee joint cavity by epidermis-sticking external preparation for patients with osteoarthritis

Measurement of the penetration effect of S-flurbiprofen into the knee joint cavity by epidermis-sticking external preparation for patients with osteoarthritis - Measurement of penetration effect of S-flurbiprofen into the knee joint cavity

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000027847

Enrollment

100

Registered

2017-06-21

Start date

2021-07-20

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis of the knee

Interventions

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1) To recognize the change of grade 2 or more in Kellgren-Lawrence classification in knee X-ray photography. (2) It is not neuropathic arthropathy. (3) No arthritis caused by factors other than osteoarthritis (rheumatoid arthritis etc.) is not merged. (4) To meet adaptation criteria for knee replacement surgery in the OARSI recommendation on the management of osteoarthritis of the osteoarthritis (end of adaptation by the committee for formulation of guideline for knee osteoarthritis of the Japanese Orthopedic Society). (5) There is no operation history on the knee joint in the past. (6) The age at the time of case registration is 50 years old and under 80 years old.

Exclusion criteria

Exclusion criteria: Patients complicated with arthritis (rheumatoid arthritis etc.) caused by factors other than osteoarthritis.

Design outcomes

Primary

Measure	Time frame
S - flurbiorofen lumber for external use (containing S - flurbiorofen 40 mg) 12 hours before the start of surgery to the knee joint on the scheduled side of the target patient. Just before surgery, external lumber is removed, joint fluid of bilateral knee joints is collected under spinal anesthesia, and blood sampling is performed from the cranial vein of the upper arm. Measurement of the concentration of S-flurbiprofen in the harvested synovial fluid and plasma.	—

Measure

Time frame

S - flurbiorofen lumber for external use (containing S - flurbiorofen 40 mg) 12 hours before the start of surgery to the knee joint on the scheduled side of the target patient. Just before surgery, external lumber is removed, joint fluid of bilateral knee joints is collected under spinal anesthesia, and blood sampling is performed from the cranial vein of the upper arm. Measurement of the concentration of S-flurbiprofen in the harvested synovial fluid and plasma.

—

Countries

Japan

Contacts

Public ContactIchiro Tsukamoto, MD

Kindai University Hospital Department of Orthopaedic Surgery

tsukamoto@med.kindai.ac.jp072-366-0221

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026