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Intake of synthetic versus natural folate and clinical outcomes in non-muscle-invasive bladder cancer

Intake of synthetic versus natural folate and clinical outcomes in non-muscle-invasive bladder cancer - Folate intake and treatment outcomes in early stage bladder cancer patients

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
JPRN
Registry ID
JPRN-UMIN000027617
Enrollment
600
Registered
2017-06-03
Start date
1997-01-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bladder cancer

Interventions

None listed

Sponsors

The University of Texas MD Anderson Cancer Center
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Non-muscle-invasive bladder (Ta, Tis, and T1) patients who were newly diagnosed (within 1 year before recruitment) between 1997 and 2012, with histologic confirmation, and were previously untreated with chemotherapy or radiotherapy. For the present study, we limited the analysis to non-Hispanic whites who account for the majority of the study population.

Exclusion criteria

Exclusion criteria: Patients with outlying (i.e., outside the interval delimited by the 25th percentile minus 1.5 times the interquartile range and the 75th percentile plus 1.5 times the interquartile range) or implausible (i.e., <500 kcal/d or >5,000 kcal/d) energy intakes.

Design outcomes

Primary

MeasureTime frame
Tumor recurrence was defined as a newly found bladder tumor during follow-up, and progression was defined as the transition from non-muscle-invasive to invasive or metastatic disease during follow-up.

Secondary

MeasureTime frame
Stratified associations by treatments. Folate intake and five tumor characteristics at diagnosis: focality, size, grade, stage, and concomitant carcinoma in situ.

Countries

North America

Contacts

Public ContactDr. Huakang Tu

The University of Texas MD Anderson Cancer Center Division of Cancer Prevention & Population Sciences

htu2@mdanderson.org7137456699

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026