The relation between increased platelet reactivity during PCI and peri-procedural myocardial injury: comparison of clopidogrel with prasugrel

The relation between increased platelet reactivity during PCI and peri-procedural myocardial injury: comparison of clopidogrel with prasugrel - The relation between increased platelet reactivity during PCI and peri-procedural myocardial injury

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000027582

Enrollment

160

Registered

2017-10-01

Start date

2017-10-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

effort angina

Interventions

Patients in clopidogrel group underwent dual anti-platelet therapy with clopidogrel (75 mg daily) and aspirin (100 mg daily) between 7 days before PCI and 30 days after PCI. Patients in prasugrel gr

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with effort angina scheduled for elective PCI.

Exclusion criteria

Exclusion criteria: hemorrhagic tendency severe liver dysfunction(child-pugh grade C) severe renal dysfunction (eGFR <30mL/min/1.73m2) severe hypertension (systolic blood pressure >180) have past history of cerebral infarction or transient ischemic attack have intolerance with other thienopyridine derivative

Design outcomes

Primary

Measure	Time frame
the occurrence rate of PMI (definition of PMI) High-sensitive Troponin-T (hs-TnT) was measured before and 24 hours after PCI. In patients with normal (<99th percentile URL) baseline hs-TnT concentrations, PMI was defined as elevation of hs-TnT >5*99th percentile URL 24 hours after PCI. If the baseline hs-TnT values are elevated and are stable or falling, then a rise of > 20% is required for the diagnosis of PMI.	—

Measure

Time frame

the occurrence rate of PMI (definition of PMI) High-sensitive Troponin-T (hs-TnT) was measured before and 24 hours after PCI. In patients with normal (<99th percentile URL) baseline hs-TnT concentrations, PMI was defined as elevation of hs-TnT >5*99th percentile URL 24 hours after PCI. If the baseline hs-TnT values are elevated and are stable or falling, then a rise of > 20% is required for the diagnosis of PMI.

—

Secondary

Measure	Time frame
PRU value before and after PCI. the serial change in platelet reactivity during elective PCI. the correlation between the occurrence of PMI and PRU value before PCI and after PCI. cardiovascular event and hemorrhagic event within 30 days after PCI.	—

Countries

Japan

Contacts

Public ContactYusuke Kawai

Okayama City Hospital Department of Cardiovascular Medicine

jamkuhta@yahoo.co.jp086-737-3000

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026