A Prospective trial of Decompression Surgery and Intraoperative Radiotherapy for Metastatic Epidural Spinal Cord Compression

A Prospective trial of Decompression Surgery and Intraoperative Radiotherapy for Metastatic Epidural Spinal Cord Compression - Intraoperative Radiotherapy for Metastatic Epidural Spinal Cord Compression

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000027519

Enrollment

Registered

2017-06-15

Start date

2017-06-15

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Metastatic Epidural Spinal Cord Compression

Interventions

Surgical decompression and Intra-operative radiotherapy of 20 Gy. Adjuvant external body radiotherapy of 30 Gy in 10 fractions

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. pathological or clinical diagnosis of primary cancer (including sarcoma) 2. spine metastases confirmed by images 3. Symptoms by the tumor 4. Bilsky grade is more than Ib or SINS is potentially unstable/unstable 5. Age; 20- 6. prognosis is expected more than 6 months 7. Written informed consent

Exclusion criteria

Exclusion criteria: 1. Radiosensitive histology 2. untlerable to surgery 3. complete paralysis more than 48 hours 4. impossible to conduct decompression surgery

Design outcomes

Primary

Measure	Time frame
Ambulatory function, local control at 1 year	—

Secondary

Measure	Time frame
local control at 3 years, OS, local progression free survival, pattern of failure, pain response, Adverse events	—

Countries

Japan

Contacts

Public ContactKei Ito

Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital Division of Radiation Oncology, Department of Radiology

keiito@cick.jp03-3823-2101

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026