Full-thickness articular cartilage defects of the knee due to trauma or osteochondritis dissecans
Conditions
Interventions
JACC (autologous cultured cartilage) will be prepared by Japan Tissue Engineering Co., Ltd following established protocol and delivered to our hospital with certified quality. Patients will be admit
Sponsors
Hiroshima University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Over 13 year old 2. Diagnosed as chondral lesion due to trauma or osteochondritis dissecans of the knee 3. Lesion size is over 4cm2 4. Patients consented to being enrolled this study with specific form
Exclusion criteria
Exclusion criteria: 1. Patient who is diagnosed as oteoarthritis of the knee 2. Patient who is diagnosed or suspected malignant tumor 3. Patient who has complications and considered as inappropriate case by orthopaedic surgeon in charge. 4. Hypersensitive patients against gentamicin, amphotericin B, or amnoglycoside. 5. Hypersensitive patients against intradermal injection of atelocollagen or bovine product. 6. Patient who has allergic reaction to bovine or swine. 7. Patient who is diagnosed as rheumatoid arthritis, psoriatic arthritis, systemic lupus erythematosus, dermatomyositis, polymyositis, autoimmune thyropathy, multiple arteritis, scleroderma, ulcerative colitis, Crohn's disease, Sjogren's syndrome, Reiter's syndrome, mixed connective tissue dissase. 8. Patient who has past history about anaphylactic shock. 9. Patient who has hypersensitive against atelocollagen. 10. Patient who is considered as inappropriate case by orthopaedic surgeon in charge.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical score from Knee Injury and Osteoarthritis Outcome Score (KOOS) sheet obtained at registration, 26 weeks, and 52 weeks after implantation. | — |
Countries
Japan
Contacts
Public ContactMasakazu Ishikawa
Hiroshima University Hospital Department of Orthopaedic Surgery
Outcome results
None listed