retrospective study of gamma knife radiosurgery for brain metastases of small cell lung carcinoma after whole brain radiotherapy

retrospective study of gamma knife radiosurgery for brain metastases of small cell lung carcinoma after whole brain radiotherapy - JLGK1701 study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000027490

Enrollment

300

Registered

2017-06-30

Start date

2017-05-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

brain metastases of small cell lung carcinoma

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: all of uncontrolled brain metastases of small cell lung carcinoma after whole brain radiotherapy were treated with first and single session gamma knife radiosurgery

Exclusion criteria

Exclusion criteria: 1 gamma knife radiosurgery before whole brain radiotherapy 2 presence of leptomeningeal dissemination 3 surgery for brain metastases before gamma knife radiosurgery 4 intracranial metastases outside of brain 5 Karnofsky performance status <70 or no expectation for improvement of KPS >60 after gamma knife radiosurgery 6 gamma knife radiosurgery without gadlinium enhancement MRI 7 the number of brain metastases >10 or the total volume of brain metastases >15ml or the volume of maximum brain metastasis >10ml

Design outcomes

Primary

Measure	Time frame
overall survival, local control, new lesion free survival, functional preservaton, neurological death, side effect	—

Countries

Japan

Contacts

Public ContactKiyoshi Nakazaki

BraiIn Attack Center Ota Memorial Hospital neurosurgery

nakazaki@shouwa.or.jp084-931-8650

Outcome results