amyotrophic lateral sclerosis
Conditions
Sponsors
Department of Neurology Chiba University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Over 20 year old 2) Probable of definite ALS disease by Awaji electrophysiological criteria 3) Subjects provided informed consent.
Exclusion criteria
Exclusion criteria: 1) Patient without ability to comprehend informed consent 2) Patient with uncompensated medical illness 3) Patient with cardiac disease (myocardial infarction, valvular disease and cardiomyopathy etc.) 4) Patient with arrhythmia (incomplet AV-block and bundle branch block etc.) 5) Patient with sodium channel disorders, like Brugada syndrome 6 )Patient already administered anti-arrhythmic drug which prolongs PR interval 7) Pregnant or breast-feeding women 8) Patient with forced vital capacity of< 60% predicted 9) Patient already performed tracheotomy or tube feeding 10) Patient take any other experimental agents 3 months before. 11) Not enough CMAP amplitude in the median nerve to be performed nerve excitability test 12) Patient plan to change medicine which affects nerve excitability 13) Familial ALS 14) Patient who is judged inappropriate for this trail by doctors responsible for this trial
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Safety for 4 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| nerve excitability fasciculation muscle cramp | — |
Countries
Japan
Contacts
Public ContactKazumoto Shibuya
Chiba University Hospital Department of Neurology
Outcome results
None listed