Research to validate the correlation of the quantitative fluorescence intensity with 5-aminolevulinic acid and malignancy index calculated with intra-operative rapid measurement of the amount of DNA in the tumors

Research to validate the correlation of the quantitative fluorescence intensity with 5-aminolevulinic acid and malignancy index calculated with intra-operative rapid measurement of the amount of DNA in the tumors - Research to validate the correlation of the quantitative fluorescence intensity with 5-aminolevulinic acid and malignancy index calculated with intra-operative rapid measurement of the amount of DNA in the tumors

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000027467

Enrollment

Registered

2017-05-23

Start date

2017-05-16

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

malignant brain tumors

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients planed fluorescence guided surgery with 5-ALA

Exclusion criteria

Exclusion criteria: i) the patients with hypersensitivity for 5-ALA ii) the patients with a history of porphyria iii) the patients with severe liver disfunction

Design outcomes

Primary

Measure	Time frame
The correlation of fluorescence radiance and the malignancy index calculated with the intraoperative rapid measurement of DNA per single cells.	—

Secondary

Measure	Time frame
Heterogeneity of malignancy calculated with the intraoperative rapid measurement of intracellular amount of DNA in the weak fluorescent area.	—

Countries

Japan

Contacts

Public ContactNaokado Ikeda

Osaka Medical College Department of Neurosurgery and Endovascular Neurosurgery

neu098@osaka-med.ac.jp+81-72-683-1221

Outcome results