Food allergy
Conditions
Interventions
s milk concentrate for 12 hours a day for 48 weeks
Cutaneous application of hydrogel patch containing cow'
s milk concentrate for 12 hours a day for 24 weeks
Sponsors
National Hospital Organization Mie National Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Milk allergy diagnosed by oral food challenge (OFC) without tendency of natural outgrow 2) Milk dose threshold of OFC =<3ml(total dose) and underwent cutaneous application of cow's milk concentrate-containing hydrogel patch or hydrogel patch without containing antigen for 24 weeks. 3)Milk dose threshold of OFC =<3ml(total dose) after intervetion of 2).
Exclusion criteria
Exclusion criteria: 1)patients who have heart, liver and kidney diseases 2)patients with ncontrolled asthma or atopic dermatitis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of the subjects who tolerate more than 3 ml of milk (total dose) at oral milk challenge after the treatment for 48 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Change of dose threshold in oral milk challenge after 24 weeks of treatment 2.Safety:local reaction,systemic immediate-type allergic reaction and other 3.Prick test 4.Specific IgE and IgG4 | — |
Countries
Japan
Contacts
Public ContactYu Kuwabara
National Hospital Organization Mie National Hospital Allergy center
Outcome results
None listed