Predictive performance of target controlled infusion system in head down position

Predictive performance of target controlled infusion system in head down position - Propofol pharmacokinetics in head down position

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000027434

Enrollment

Registered

2017-05-22

Start date

2017-05-22

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diseases which require head down position with pneumoperitoneum during surgery

Interventions

Propofol administration using target controlled infusion system targeting 3 mcg/ml during anesthesia for surgery

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: Male patients who are scheduled to undergo elective surgery in head down position and provided written informed consent whose physical status are American Society of Anesthesiologists classification 1 or 2.

Exclusion criteria

Exclusion criteria: Exclusion criteria includes known allergy to propofol; psychoneurotic disorders; psychiatric pharmacotherapy; chronic use of NSAIDs or opioids; cirrhosis; anemia (hemoglobin <8 g/dL); and those who were considered inadequate.

Design outcomes

Primary

Measure	Time frame
Bias (median prediction error) and accuracy (median absolute prediction error) of predicted propofol concentrations compared to measured blood propofol concentrations. Blood samples will be collected during general anesthesia for surgery. Statistical analysis will be performed after the collection of a certain number of samples.	—

Countries

Japan

Contacts

Public ContactShinju Obara

Fukushima Medical University Surgical Operation Department

masui@fmu.ac.jp0245471342

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026