Which is the best ultra-rapid acting insulin to improve postprandial glycemic variability? Comparison of insulin glulisine vs. insulin lispro vs. insulin aspart using FreeStyle Libre Pro: randomised triple crossover study

Which is the best ultra-rapid acting insulin to improve postprandial glycemic variability? Comparison of insulin glulisine vs. insulin lispro vs. insulin aspart using FreeStyle Libre Pro: randomised triple crossover study - Comparison of insulin glulisine vs. insulin lispro vs. insulin aspart using FreeStyle Libre Pro: randomised triple crossover study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000027368

Enrollment

Registered

2017-05-17

Start date

2017-05-17

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes

Interventions

FreeStyle Libre Pro is worn after admission. insulin glulisine are evaluated on day 3 and day 4. Then, insulin lispro are evaluated on day 8 and day 9. Then, insulin aspart are evaluated on day 13 and

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: type 2 diabetic patients medicated with basal+bolus therapy (insulin glulisine+ insulin glargine 300 U/ml) for 3 month or longer

Exclusion criteria

Exclusion criteria: Patients with severe renal dysfunction (serum creatinine level more than 2.0 mg/dL) Patients who were aware that they were hypoglycemic and took glucose tablets Patients considered not suitable for participation due to medical reasons

Design outcomes

Primary

Measure	Time frame
08:00 to 24:00 percentage of time in target range (70~140 mg/dL)	—

Secondary

Measure	Time frame
08:00 to 24:00 mean absolute glucose (MAG) 08:00 to 24:00 glycemic variability percentage (GVP) 08:00 to 24:00 mean glucose level 08:00 to 24:00 standard deviation (SD) 08:00 to 24:00 coefficient of variation (CV) Highest postprandial glucose level within 3 hours after each meal Differences between preprandial and highest postprandial glucose level for each meal Post-breakfast glucose gradient AOC (<70 mg/dL) for glycemic variability (0:00~8:00, 8:00~12:00, 12:00~18:00, 18:00~24:00) M-value (8:00~24:00,24h) MAGE ADRR Time from start of meal to the highest postprandial glucose level MODD 08:00 to 24:00 low blood glucose index (LBGI)	—

Measure

Time frame

08:00 to 24:00 mean absolute glucose (MAG) 08:00 to 24:00 glycemic variability percentage (GVP) 08:00 to 24:00 mean glucose level 08:00 to 24:00 standard deviation (SD) 08:00 to 24:00 coefficient of variation (CV) Highest postprandial glucose level within 3 hours after each meal Differences between preprandial and highest postprandial glucose level for each meal Post-breakfast glucose gradient AOC (<70 mg/dL) for glycemic variability (0:00~8:00, 8:00~12:00, 12:00~18:00, 18:00~24:00) M-value (8:00~24:00,24h) MAGE ADRR Time from start of meal to the highest postprandial glucose level MODD 08:00 to 24:00 low blood glucose index (LBGI)

—

Countries

Japan

Contacts

Public ContactSoichi Takeishi

General Inuyamachuo Hospital Department of Diabetes

souichi19811225@yahoo.co.jp0568-62-8111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026