Low-dose gamma knife radiosurgery plus whole-brain radiation therapy for multiple brain metastases: a multi-institutional prospective study

Low-dose gamma knife radiosurgery plus whole-brain radiation therapy for multiple brain metastases: a multi-institutional prospective study - Low-dose gamma knife radiosurgery plus whole-brain radiation therapy for multiple brain metastases: a multi-institutional prospective study

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000027361

Enrollment

Registered

2017-05-17

Start date

2014-06-07

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Metastatic brain tumors

Interventions

Perform low-dose GK plus WBRT for multiple (including 10 or more) BMs and large BMs over 3 cm with or without meningeal dissemination

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1)Either a,b or c (a)10 or more BMs (b)Tumor diameter > 3, < 4 cm) (c)BMs with meningeal dissemination (2)Karnofsky Performance Status (KPS) score>=70 KPS<70 due to neurological symptom (3)No history of cranial radiation therapy or craniotomy

Exclusion criteria

Exclusion criteria: (1)Active double cancer (2)In pregnancy or lactation period (3)Psychiatric disorder (4)Allergy to gadolinium contrast or contraindication of MR imaging

Design outcomes

Primary

Measure	Time frame
Over all survival	—

Secondary

Measure	Time frame
The cumulative incidence of intracranial recurrence, adverse event	—

Countries

Japan

Contacts

Public ContactAkifumi Miyakawa

Nagoya City University Graduate School of Medical Sciences Department of Radiology

amiyakawa21@triton.ocn.ne.jp052-853-8274

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026