Single arm and open-label study evaluating the effect of fucoidan intake on proviral load in carriers with human T-cell leukemia virus type-I

Single arm and open-label study evaluating the effect of fucoidan intake on proviral load in carriers with human T-cell leukemia virus type-I - Effect of fucoidan on proviral load in carriers with HTLV-1

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000027358

Enrollment

Registered

2017-05-17

Start date

2016-08-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Human T-cell leukemia virus type-I (HTLV-1) infection

Interventions

Fucoidan-drink (fucoidan 1 g/50 ml/bottle, 3 bottles/day)for 6 months

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Those who are diagnosed as HTLV-1 carrier in Kariyushi-Hospital on Ishigaki Island, Okinawa, Japan 2. Aged 20 years or older 3. HTLV-1 proviral load >= 4 copies/100 peripheral mononuclear cells 4. Available to participate within the study time frame 5. Consent to participate for the study

Exclusion criteria

Exclusion criteria: 1. Those who have developed HTLV-1 associated diseases (ATL, HAM/TSP, HU) 2. Those who suffered any other malignant tumor and receive medical treatment 3. Those who suffer from systemic infection 4. Those who receive medical treatment that might affect HTLV-1 proviral load

Design outcomes

Primary

Measure	Time frame
HTLV-1 proviral load (real-time PCR method)	—

Secondary

Measure	Time frame
fucoidan concentration in urine (ELISA), Immune function (flow cytometric analysis of cell surface marker)	—

Countries

Japan

Contacts

Public ContactMegumi Kuba-Miyara

University of the Ryukyus Laboratory of Hematoimmunology, School of Health Sciences, Faculty of Medicine

kubame93@med.u-ryukyu.ac.jp+81-98-895-3331(ext.2652)

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026