Clinical evaluations of autologous fibrin glue and polyglycolic acid sheets as preventing esophageal stricture after endoscopic submucosal dissection of superficial esophageal neoplasms

Clinical evaluations of autologous fibrin glue and polyglycolic acid sheets as preventing esophageal stricture after endoscopic submucosal dissection of superficial esophageal neoplasms - The efficacy of shielding method with autologous fibrin glue and polyglycolic acid sheets for the prevention of postoperative stricture after esophageal endoscopic submucosal dissection

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000027336

Enrollment

Registered

2017-05-15

Start date

2017-05-15

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

superficial esophageal neoplasms

Interventions

shielding with autologous fibrin glue and polyglycolic acid sheets

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. The patient must be greater than 20 years old. 2. Superficial esophageal squamous cell carcinoma or high grade intraepithelial neoplasia is diagnosed pathologically. 3. The patient is supposed to undergo ESD in our institute. 4. The mucosal defect is supposed to be more than the half circumference of esophagus.

Exclusion criteria

Exclusion criteria: 1. The mucosal defect is supposed to be entire circumference of esophagus. 2. The lesion is supposed to be SM or deeper. 3. The level of Hb is under 11. 4. The performance is poor and it is difficult to undergo ESD. 5. Severe cardiac disease (Aortic stenosis, etc) 6. The patient has a history of fever, diarrhea, or dental extraction within 72 hours. 7. Others

Design outcomes

Primary

Measure	Time frame
The incidence of postoperative esophageal stricture (within 26 weeks after ESD)	—

Secondary

Measure	Time frame
The number of sessions of endoscopic balloon dilatation required to resolve any strictures, and the interval between ESD and developing the regenerating epithelium.	—

Countries

Japan

Contacts

Public ContactToshiro Iizuka

Toranomon Hospital Department of Gastroenterology

t-iizuka@toranomon.gr.jp03-3588-1111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026