Influence of glaucoma on circadian biological rhythm

Influence of glaucoma on circadian biological rhythm - Influence of glaucoma on circadian biological rhythm

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000027299

Enrollment

200

Registered

2017-05-11

Start date

2017-05-11

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

glaucoma

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients meets glaucoma criteria for Taijimi study.

Exclusion criteria

Exclusion criteria: 1)severe mental illness and dementia 2)severe corneal opacity and cataract 3)vitreous hemorrhage 4)severe retinal and choroidal disease

Design outcomes

Primary

Measure	Time frame
Prevalence of circadian rhythm-related disorder (depressive symptoms, sleep disturbance and cognitive impairment) 1) Depressive symptoms (Geriatric Depression Scale:GDS) 2) Objective sleep quality (measured using actigrapgh) 3) Subjective sleep quality (Pittsburgh Sleep Quality Index:PSQI) 4) Sleepiness (Epworth Sleepiness Scale: ESS) 5) Cognitive function (Mini Mental State Examination: MMSE)	—

Secondary

Measure	Time frame
1 Ophthalmic outcomes 1) Visual acuity and intraocular pressure 2) Retinal and Choroidal thickness(OCT: optical coherence tomography) 3) OCT angiography 4) Visual field 5) ocular circulation (LSFG: Laser Speckle Flowgraphy) 6) Post Illumination Pupil Response (PIPR) 7) Contact Dermatitis 8) The 25-itemNational Eye Institute Visual Function Questionnaire (NEI VFQ-25) 2 Glucose-lipid metabolism outcomes 1) FPG HbA1c 2) TG T-chol LDL chol and HDL chol BMI(Body Mass Index) Abdominal circumference 3 Circadian rhythm outcomes 1) 6-sulfatoxymelatonin(aMT6-s)in a morning spot urine sample 2) Circadian activity rhythm 3) skin temperatures 4) ambulatory blood pressure monitoring (ABPM) 4 Vascular endothelial function Asymmetric Dimethylarginine (ADMA) 5 Neurotrophic factor Brain-derived neurotrophic factor (BDNF) 6 Residential characteristics 7 Dietary habit 8 Physical activity	—

Measure

Time frame

1 Ophthalmic outcomes 1) Visual acuity and intraocular pressure 2) Retinal and Choroidal thickness(OCT: optical coherence tomography) 3) OCT angiography 4) Visual field 5) ocular circulation (LSFG: Laser Speckle Flowgraphy) 6) Post Illumination Pupil Response (PIPR) 7) Contact Dermatitis 8) The 25-itemNational Eye Institute Visual Function Questionnaire (NEI VFQ-25) 2 Glucose-lipid metabolism outcomes 1) FPG HbA1c 2) TG T-chol LDL chol and HDL chol BMI(Body Mass Index) Abdominal circumference 3 Circadian rhythm outcomes 1) 6-sulfatoxymelatonin(aMT6-s)in a morning spot urine sample 2) Circadian activity rhythm 3) skin temperatures 4) ambulatory blood pressure monitoring (ABPM) 4 Vascular endothelial function Asymmetric Dimethylarginine (ADMA) 5 Neurotrophic factor Brain-derived neurotrophic factor (BDNF) 6 Residential characteristics 7 Dietary habit 8 Physical activity

—

Countries

Japan

Contacts

Public ContactTadanobu Yoshikawa

Nara Medical University School of Medicine Department of Ophthalmology

yoshikat@naramed-u.ac.jp0744-22-3051

Outcome results