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Analysis of Airway Inflammatory state alteration after intravenous L-Arginine loading

Analysis of Airway Inflammatory state alteration after intravenous L-Arginine loading - Alteration of Airway Inflammatory state after intravenous L-Arginine loading(AILA)

Status
Unknown
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000027260
Enrollment
15
Registered
2017-05-07
Start date
2017-02-06
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Children who are required growth hormone (GH) stimulation tests to diagnose GH deficiency. These are children whose heights are two standard deviations (SD) below the mean for age and sex, and/or whose growth velocities are 1.5 SD below the mean for age and sex over 2 years&#39

Interventions

Dosing 500mg/kg L-arginine (maximal dose 30g) intravenous drip in 30minutes

Sponsors

Osaka City University Graduate School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Participants are scheduled to be examined by intravenous L-arginine loading test with short stature less than -2.0 standard deviation (SD) and/or low growth velocity <-1.5SD over 2 years of follow-up for age and sex, or another reasons their pediatric endocrinologist judge the L-arginine provocative test is necessary. They should be over 2 years old and under 16 years old , and give informed consent on the basis that the study is approved by each local ethics committee.

Exclusion criteria

Exclusion criteria: Exclusion criteria are following items 1)Patients who are diagnosed with allergy of L-arginine 2) Patients who have used any steroid medications within one month 3) Either the investigator or the co-investigator judged as inappropriate patient for this clinical research

Design outcomes

Primary

MeasureTime frame
The alteration rate of oxidative stress level before L-arginine loading and 120 minutes after.—

Secondary

MeasureTime frame
In addition to the above mentioned items, the following items is investigated, including; (1) The alteration rate of oxidative stress level, arginine level, pteridines level before L-arginine loading and 30,60,90,120 minutes after and next day in serum. (2) Correlation between FeNO and oxidative stress level at each point. (3) Correlation between FeNO and pteridines level at each point. (4) Correlation between oxidative stress level and pteridines level at each point.—

Countries

Japan

Contacts

Public ContactSaki Kasuga

Osaka City University Graduate School of Medicine Department of Pediatrics

m2017993@med.osaka-cu.ac.jp06-6645-3816

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026