FindTrial
Sign In

Antipruritic effect of prophylactic pentazocine combined with ultra-low-dose naloxone on intrathecal opioids-induced pruritus after cesarean delivery: a double-center prospective, controlled trial

Antipruritic effect of prophylactic pentazocine combined with ultra-low-dose naloxone on intrathecal opioids-induced pruritus after cesarean delivery: a double-center prospective, controlled trial - Antipruritic effect of pentazocine combined with ultra-low-dose naloxone on opioids-induced pruritus

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000027226
Enrollment
100
Registered
2017-05-08
Start date
2017-05-09
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Opioids-induced pruritus

Interventions

After delivery of the baby, the parturient women were randomized to intravenously receive 15 mg of pentazocine + ultra-low-dose Naloxone. After delivery of the baby, the parturient women were randomiz

Sponsors

Department of Anesthesiology, Shimane University Faculty of Medicine
Lead Sponsor
Department of Anesthesiology, Hamada Medical Center
Collaborator

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: ASA physical status 2-3 patients who presented for elective cesarean delivery under spinal anesthesia were included in this study. written informed consent was obtained from each patient enrolled in the study.

Exclusion criteria

Exclusion criteria: 1) Emergency cesarean delivery 2) Allergy to pentazocine, naloxone, morphine, fentanyl, bupivacaine, or levobupivacaine 3) Preexisting pruritus 4)Patient with preeclampsia,diabetes mellitus; or neurologic disease.

Design outcomes

Primary

MeasureTime frame
the incidence of opioid-induced pruritus within the first 24 hr after administration of opioids.—

Countries

Japan

Contacts

Public ContactNoritaka Imamachi

Shimane University Faculty of Medicine Department of Anesthesiology

imamachi@med.shimane-u.ac.jp0853-20-2295

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026